5/9/2023 0 Comments Lineage w regionsThe Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension. Current Biology 2007 17(2):165–72.Ĭurtis MA, Kam M, Nannmark U, et al. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Developmental Biology 2006 291(2):300–13.Ĭlement V, Sanchez P, de Tribolet N, Radovanovic I, Ruiz i Altaba A. LeX is expressed by principle progenitor cells in the embryonic nervous system, is secreted into their environment and binds Wnt-1. Evidence of newly generated neurons in the human olfactory bulb. Mutational and expression analysis of the reelin pathway components CDK5 and doublecortin in gangliogliomas. Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Journal of Neuroscience 2006 26(25):6781–90.īachoo RM, Maher EA, Ligon KL, et al. Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses. Nature Reviews Neuroscience 2001 2(4):287–93.Īssanah M, Lochhead R, Ogden A, Bruce J, Goldman J, Canoll P. A unified hypothesis on the lineage of neural stem cells. Neuron 2004 41(5):683–6.Īlvarez-Buylla A, Garcia-Verdugo JM, Tramontin AD. For the long run: maintaining germinal niches in the adult brain. Proceedings of the National Academy of Sciences of the United States of America 2000 97(23):12846–51.Īlvarez-Buylla A, Lim DA. Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. This process is experimental and the keywords may be updated as the learning algorithm improves.Īboody KS, Brown A, Rainov NG, et al. These keywords were added by machine and not by the authors. While a direct link has yet to be established between any one of these cell types and tumor formation, the different cell lineages arising from the ventricular and subventricular zone during development in the adult may offer clues in deciphering the origin of various tumor subtypes, including gliomas. Possible candidate cells-of-origin include neuroepithelial cells, radial glia, astrocytic neural stem cells (‘B cells’), transient amplifying precursors (‘C cells’) of the adult subventricular zone (SVZ), or oligodendrocyte progenitor cells of the white matter. Phenotypic and behavioral similarities between gliomas and adult neural stem cells raise the possibility that stem or progenitor cells can give rise to gliomas. More recently, however, this hypothesis has been challenged by the discovery of stem cell and progenitor populations residing in the postnatal brain, which may themselves serve as an origin of brain tumors. Astrocytes and oligodendrocytes, once thought to be the sole dividing cells in the postnatal brain, were assumed to represent the cellular compartment most susceptible to transformation. Historically, the neoplastic transformation of fully differentiated glia was widely assumed to be the only mechanism for gliomagenesis. Gliomas are a primary cancer of the brain and one of the most lethal cancers known to man.
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